Descripción
About the position Applications are invited for a 3-year position as PhD student in epigenetics and obesity research at the newly established K.G Jebsen Centre of Obesity ReseArch (CORA). The position will be affiliated to Yvonne Böttcher’s research group at the Department of Clinical Molecular Biology (EpiGen) at Institute of Clinical Medicine, UiO, physically located at Campus Ahus (Akershus University Hospital). The project aims at investigating molecular mechanisms underlying weight regain and long-term weight loss maintenance using advanced molecular biology techniques. In particular, the project will investigate amongst others the concept of epigenetic memory of obesity in humans and closely collaborate with clinical environments involved in treatment of obesity The applicant will be involved in tasks related to epigenetic and epitranscriptomic mechanisms potentially being implicated in the regulation of human body weight and adipose tissue biology in general. The PhD project aims at investigating molecular mechanisms underlying weight regain and maintenance using advanced molecular biology techniques. Project description Obesity is a growing health problem worldwide. Metabolic surgery or use of GLP-1R analoga are efficient methods to induce significant weight loss in individuals with obesity. However, many individuals struggle to maintain healthier body weight and often suffer from regain weight after treatment. The newly established K.G. Jebsen Center for obesity research ( CORA ), lead by Prof. Yvonne Böttcher, aims to understand the biological mechanisms underlying weight regain and obesity relapse, identify individuals at risk, and develop strategies for sustained weight loss and long-term weight maintenance. Yvonne Böttcher’ s research group ( https://functionalgeneticsofobesity.wordpress.com/ ) is investigating the role of epigenetic mechanisms in obesity, the molecular mechanisms imposed by DNA, RNA and histone modifications and their potential interpl