Descripción
We are looking for two PhD candidates to develop and validate innovative MRI-based outcome measures for monitoring disease activity and progression in cerebral adrenoleukodystrophy (C-ALD). POLARIS doctoral network POLARIS is a European Marie Skłodowska-Curie Doctoral Network focused on accelerating therapy development for leukodystrophies: rare genetic disorders affecting the brain's white matter. The network aims to strengthen the full translational pathway, from understanding disease mechanisms and developing disease models to preclinical therapy testing, clinical readiness and patient-informed treatment priorities. To achieve this, POLARIS brings together expertise in leukodystrophy biology, advanced disease models, therapeutic innovation, biomarker development, clinical translation, patient engagement, and ethical, regulatory and health-economic aspects of therapy development. The network will train a cohort of doctoral candidates in an international and interdisciplinary environment, combining academic research, industry-based preclinical development, secondments, network-wide training and transferable-skills development. PhD projects As a PhD candidate, you will develop and validate innovative MRI-based outcome measures to monitor disease activity and progression in cerebral adrenoleukodystrophy (C-ALD). Two complementary PhD positions are available within the same multidisciplinary research programme at the Paris Brain Institute. Depending on your background, your work will focus on either the clinical and neuroradiological aspects of advanced MRI or the computational and image-analysis aspects of the research. You will investigate the sensitivity, specificity, and clinical relevance of state-of-the-art quantitative MRI (qMRI) techniques for assessing disease activity and progression in C-ALD. Particular emphasis will be placed on techniques including diffusion tensor imaging (DTI) and MR perfusion, which have shown promise as imaging biomarkers but requir f