Descripción
Are you interested in studying the cellular pathways driving Alzheimer’s disease using human autopsy tissue and cell culture models? Come join our Neuropathology Research team and work together with experts in human brain tissue research and state-of-the- art disease modelling. Alzheimer’s disease (AD) is the most common and currently incurable neurodegenerative disorder. It is characterized by the aggregation of tau and Aβ proteins in the brain. However, the neuropathological picture is often more complex than the aggregation of these two proteins alone. More than half of people with AD show additional aggregation of proteins associated with other neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. In this PhD project, you will investigate the mechanisms underlying the emergence of mixed neuropathologies in the brains of people with AD. You will work at the intersection of different neurodegenerative diseases and use human autopsy brain tissue, transcriptomics and induced pluripotent stem cell (iPSC)-based cell culture models. Your research will contribute to identifying disease mechanisms in AD, with potential relevance to other neurodegenerative disorders. During this four-year PhD project, you will work closely with molecular neuroscientists, neuropathology experts and bioinformaticians Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page. You will investigate the biological mechanisms underlying mixed neuropathologies in Alzheimer’s disease. Your work combines human brain tissue research with advanced molecular and cellular models. You will: perform cutting-edge transcriptomic analyses; work with iPSC-based neural cultures and develop novel disease models; work with human autopsy brain tissue from people with Alzheimer’s disease, strengthening the translational impact of your research; study biological mechanisms in Alzheimer’s disease and iden